| Primary Identifier | MGI:1197522 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 16373 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including His-Purkinje system development; kidney development; and regulation of transcription by RNA polymerase II. Acts upstream of or within mesoderm development; negative regulation of neuron differentiation; and positive regulation of neuron differentiation. Located in axon; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human IRX3 (iroquois homeobox 3). PHENOTYPE: Mice homozygous for a null allele display right bundle branch block, decreased body weight, increased energy expenditure, reduced adiposity and decreased susceptibility to diet induced obesity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
