| Primary Identifier | MGI:96538 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 16154 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable interleukin-10 binding activity and interleukin-10 receptor activity. Predicted to be involved in several processes, including interleukin-10-mediated signaling pathway; intestinal epithelial structure maintenance; and ubiquitin-dependent endocytosis. Predicted to be located in cytosol. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 28. Orthologous to human IL10RA (interleukin 10 receptor subunit alpha). PHENOTYPE: Mice homozygous for an ENU-generated null allele suffer from a severe inflammatory bowel syndrome. Mice heterozygote for an NZW variant allele have high sera levels of anti-chromatin antibodies. Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
