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Allele : Ttr<tm1Wsb> transthyretin; targeted mutation 1, William S Blaner

Primary Identifier	MGI:1857264	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Ttr
Transmission	Germline	Strain of Origin	129S/SvEv-Gpi1<c>
Is Recombinase	false	Is Wild Type	false

molecularNote

Insertion of a neomycin resistance cassette into the second exon disrupted the gene. Western blot analysis of peripheral blood using a rat polyclonal antiserum did not detect protein in homozygous mutant mice.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
ttr<->,
TTR KO,
TTR KO,
ttr<->

earliestPublication:
Episkopou V, et al. (1993) Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc Natl Acad Sci U S A 90(6):2375-9

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

50 Publication categories

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