Primary Identifier | MGI:1857121 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Agt |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
description | Human AGT and renin genes can complement the effects of the mouse null mutation (J:39934). |
molecularNote | A genomic fragment within exon 2 that codes for 114 amino acids of the encoded protein was replaced with a neomycin selection cassette. Radioimmunoassay tests confirmed that no protein was detectable in plasma of homozygous mice. |