Primary Identifier | MGI:1857458 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Fgf2 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | An Hprt minigene replaced 0.5kb of sequence containing 121bp of the proximal promoter region and exon 1. Northern blot analysis of E13.5 embryos demonstrated that no mRNA containing exon 2 and 3 sequences is detectable in homozygous mutant mice. Western blot analysis on brain tissue from homozygous mutant mice showed that the protein is absent. |