Primary Identifier | MGI:1857511 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Rxra |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
molecularNote | This allele encodes a protein that lacks the final 18 amino acids (position 450 to 467) due to a nonsense mutation introduced into exon 10. The deletion corresponds to the last alpha helical structure (helix 12) of the ligand binding domain. A floxed neo cassette was inserted into intron 9 for selection. |