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Allele : Rxra<tm1Ipc> retinoid X receptor alpha; targeted mutation 1, Pierre Chambon

Primary Identifier  MGI:1857511 Allele Type  Targeted
Attribute String  Null/knockout Gene  Rxra
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
molecularNote  This allele encodes a protein that lacks the final 18 amino acids (position 450 to 467) due to a nonsense mutation introduced into exon 10. The deletion corresponds to the last alpha helical structure (helix 12) of the ligand binding domain. A floxed neo cassette was inserted into intron 9 for selection.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Rxralpha<af2(l)>,
  • Rxr alpha AF2<I>,
  • Rxr alpha AF2<I>,
  • Rxr alpha AF2<O>,
  • Rxralpha<af2(l)>,
  • Rxr alpha AF2<O>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

16 Publication categories