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Allele : Rela<tm1Yuo> v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1, Yuichi Obata

Primary Identifier	MGI:1860444	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Rela
Inheritance Mode	Recessive	Transmission	Germline
Strain of Origin	129S/SvEv-Gpi1<c>	Is Recombinase	false
Is Wild Type	false

molecularNote

A neomycin selection cassette was inserted 3 base pairs downstream of the translation initiation codon. Northern analysis of total RNA isolated from homozygous mutant embryos showed an absence of transcript.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
relA -,
p65<->,
relA -,
p65<->

earliestPublication:
Doi TS, et al. (1997) NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J Exp Med 185(5):953-61

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

4 Carried By

0 Driven By

14 Publication categories

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