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Allele : Tlr4<tm1Aki> toll-like receptor 4; targeted mutation 1, Shizuo Akira
Primary Identifier  MGI:1860885 Allele Type  Targeted
Attribute String  Null/knockout Gene  Tlr4
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Genomic sequences encoding the transmembrane and cytoplasmic domains (amino acids 86-835) were replaced with a neomycin cassette. Northern blot analysis revealed that no mRNA is produced from this allele in splenocytes derived from homozygous mice.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • TLR4-,
  • TLR4 KO,
  • TLR4-KO,
  • TLR4-,
  • TLR4 KO,
  • TLR4-KO
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

9 Carried By

0 Driven By

732 Publication categories





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