|  Help  |  About  |  Contact Us

Allele : Cd80<tm1Shr> CD80 antigen; targeted mutation 1, Arlene H Sharpe

Primary Identifier  MGI:1861804 Allele Type  Targeted
Attribute String  Null/knockout Gene  Cd80
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin selection cassette replaced the exon encoding the IgV-like domain of the protein. RT-PCR analysis on RNA derived from spleen, thymus and LPS-stimulated B cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. FACS analysis on B cells derived from homozygous mice confirmed that no functional protein was encoded by this allele.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • CD80-,
  • CD80-,
  • B7-,
  • B7-,
  • B7.1,
  • B7-1-,
  • B7-1-,
  • B7.1
Quick Links:
 
Quick Links:
 

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

15 Carried By

0 Driven By

155 Publication categories