Primary Identifier | MGI:1926299 | Allele Type | Targeted |
Attribute String | Hypomorph | Gene | Tcf7 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A 350-bp fragment encoding part of intron IV and exon V was replaced with a neomycin cassette. A novel mRNA was detected in homozgyote thymocytes at 15% of the wild-type mRNA level. This mutant mRNA contains a splice variant of exon 4 to exon 6. This allele is considered a hypomorph. |