| Primary Identifier | MGI:2149630 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Jun |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| description | ES cell line = D3-2. Mutant ES cells failed to contribute to the liver but not to other tissues of adult chimeric mice (J:14538). A developmental analysis of chimeras showed contribution of mutant ES cell derivatives to fetal, but not to adult livers, suggesting a role in hepatocyte turnover (J:55508). |
| molecularNote | A neomycin resistance cassette replaced 703 bp of sequence that codes for the DNA binding and leucine zipper domains. Western blot analysis of E9.5 lysates did not detect wild-type protein in homozygous mutant embryos. |
