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Allele : Fgfr1<tm6Jrt> fibroblast growth factor receptor 1; targeted mutation 6, Janet Rossant

Primary Identifier  MGI:2153351 Allele Type  Targeted
Attribute String  Hypomorph Gene  Fgfr1
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A loxP flanked neomycin cassette was inserted into intron 15, and point mutations were introduced into the sequences encoding the one of the autophosphorylation sites and the PLCgamma binding site that altered the corresponding amino acids from tyrosine to phenylalanine. This is a hypomorphic allele.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • n15,
  • n15YF,
  • n15,
  • n15YF,
  • Fgfr1<n15YF>,
  • Fgfr1<n15YF>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

7 Publication categories