Primary Identifier | MGI:2154514 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Cdx1 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Insertion of a TK-neomycin resistance cassette in reverse transcriptional orientation into exon 3 introduced a premature stop codon upstream of sequences that code for the carboxy terminus, which includes the recognition helix. Western blot analysis using antibodies raised to the amino terminus of the protein did not detect protein in intestine of homozygous mutant mice. |