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Allele : Comt<tm1Kara> catechol-O-methyltransferase; targeted mutation 1, Maria Karayiorgou
Primary Identifier  MGI:2178542 Allele Type  Targeted
Attribute String  Null/knockout Gene  Comt
Transmission  Germline Strain of Origin  129S4/SvJaeSor
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin resistance cassette replaced a genomic fragment containing exons 2-4. Northern blot analysis on RNA derived from brain and liver of homozygous mice demonstrated that no detectable transcript was produced from this allele. Activity assays confirmed that no functional protein was expressed in homozygotes.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • COMT<->,
  • COMT<->,
  • COMT-ko,
  • COMT-ko
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

45 Publication categories





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