Primary Identifier | MGI:2180685 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Cd19 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 5 encoding the transmembrane domain and 7 of the 9 exons encoding cytoplamic domains were replaced with a neomycin cassette. In addition, the inserted neomycin gene introduced a stop codon. Immunohistochemical staining showed a lack of protein expression in the spleens of homozygous mutant mice. |