| Primary Identifier | MGI:2183621 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Mxd3 |
| Transmission | Germline | Strain of Origin | 129S4/SvJaeSor |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin selection cassette replaced a region spanning the start codon in exon 1 and 5.8kb of intronic sequence following exon 4. In addtion to the initial methionine, the deleted sequence encoded the Sin3-interacting domain, a conserved HGYAS motif, and the basic and helix-loop-helix regions of the bHLH leucine zipper. RT-PCR analysis and in situ hybridization confirmed the absence of transcript in homozygous mutant embryos. |
