Primary Identifier | MGI:2384183 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Shc1 |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exons 1 and 2, encoding the transcriptional start site and the amino terminals of the three known isoforms, were flanked by a single upstream loxP site and a floxed neo cassette inserted into intron 2. Transient transfection of ES cells resulted in the excision of the floxed neo cassette, leaving the first two exons surrounded by single loxP sites. |