| Primary Identifier | MGI:2383951 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Prkdc |
| Transmission | Germline | Strain of Origin | 129S4/SvJae |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The insertion of a neomycin selection cassette replaced 1 kb of sequence spanning two exons encoding amino acids 3860 through 3950. While RT-PCR analysis revealed the presence of truncated transcript in homozygous mutant mice, protein was undetected via Western blot analysis of thymic tissue. A kinase activity assay indicated functional ablation in homozygous mutant mice. |
