Primary Identifier | MGI:2386336 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Prox1 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
description | In J:53431, the original chimeric mice were crossed to four different genetic backgrounds. In three (unspecified) backgrounds mortality was 100% penetrant, whereas crosses to the NMRI background produced some surviving heterozygotes, which were used to generate homozygous embryos. |
molecularNote | A cassette containing lacZ and neo was fused in frame at the codon 224. Expression of beta-galactosidase was driven by the endogenous promoter. |