| Primary Identifier | MGI:2387570 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(CMV-cre/ERT)1Ipc |
| Strain of Origin | (C57BL/6 x SJL)F1 | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | The transgenic construct encodes a tamoxifen-dependent cre recombinase. The cre recombinase coding region was joined to a sequence encoding the ligand-binding domain of the human estrogen receptor with glycine to arginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability. The transgene was driven by the CMV promoter. |
