| Primary Identifier | MGI:2387472 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Rps6kb1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | 1.2 kb of genomic sequence, including regions encoding the conserved serine threonine kinase catalytic subdomains 8 through 10, was replaced with a neomycin selection cassette by homologous recombination. Western blot analysis of homozygous mutant mice using two antibodies directed to the amino and carboxy termini showed an absence of protein. A kinase phosphorylation assay showed no activity in homozygous mutant mice verifying a complete functional ablation. |
