Primary Identifier | MGI:2388564 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Hoxa3 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A self-excising neomycin resistance cassette was inserted into the homeodomain of Hoxa3. The targeting construct is composed of a mouse testes-specific Ace promoter fused to the cre recombinase and neomycin resistance genes. The entire construct is flanked by loxP sites and undergoes self-excision during spermiogenesis, leaving behind a single loxP insertion sequence. |