Primary Identifier | MGI:2388356 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Hoxa11 |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
description | ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or E14.1 (129P2/OlaHsd). |
molecularNote | The exon 2 homeodomain of Hoxa11 as precisely replaced with the homeodomain of Hoxa13, and a floxed neo cassette was inserted into a region 3' of the gene for positive selection. Interestingly, the 3' neo insert results in disruption of the gene. |