| Primary Identifier | MGI:2445297 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Tbxa2r |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The insertion of a PGK-neo cassette into exon 2 disrupted sequence encoding the third transmembrane domain. Though Northern blot analysis identified several aberrant transcripts in homozygous mutant mice, no normal transcript was detected. Binding assays using a labeled thromboxane agonist indicated an absence of functional receptors in both thymocytes and renal sections obtained from homozygous mutant mice. |
