| Primary Identifier | MGI:2445940 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(LPV-TAg121*E107K)1Tvd |
| Strain of Origin | (C57BL/6J X DBA/2)F2 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene consists of a lymphotrophic papovavirus (LPV) enhancer/early promoter and a mutant SV40 T antigen sequence truncated after amino acid 121 followed by 11 missense residues and carrying a C4500T point mutation. The resulting protein lacks theSV40 small t antigen and Trp53-binding region and contains a glutamic acid to lysine subsitution at position 107 in the Rb1-binding domain. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium. |
