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Allele : Dnase2a<tm1Osa> deoxyribonuclease II alpha; targeted mutation 1, Shigekazu Nagata

Primary Identifier  MGI:2449811 Allele Type  Targeted
Attribute String  Null/knockout Gene  Dnase2a
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  Exons 1-5 and part of exon 6 were replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of fetal liver RNA from E14.5 homozygous mutant embryos. No enzyme activity could be detected in homozygous mutant fetal liver extracts.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Dnase II<->,
  • Dnase II<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

24 Publication categories