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Allele : Tbxa2r<tm1Sna> thromboxane A2 receptor; targeted mutation 1, Shuh Narumiya

Primary Identifier  MGI:2667333 Allele Type  Targeted
Attribute String  Null/knockout Gene  Tbxa2r
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 2 and part of exon 3 were replaced with a neomycin resistance gene. This results in a deletion from the N terminus to the sixth transmembrane domain. Functional disruption of the gene was confirmed by loss of platelet aggregation in response to the thromboxane receptor agonist, I-BOP as well as by the absence of ligand binding activity in thymocytes.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • TP<->,
  • TP<->,
  • TP-deficient,
  • TP-deficient
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

28 Publication categories