Primary Identifier | MGI:2667333 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Tbxa2r |
Transmission | Germline | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 2 and part of exon 3 were replaced with a neomycin resistance gene. This results in a deletion from the N terminus to the sixth transmembrane domain. Functional disruption of the gene was confirmed by loss of platelet aggregation in response to the thromboxane receptor agonist, I-BOP as well as by the absence of ligand binding activity in thymocytes. |