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Allele : H2ax<tm1Fwa> H2A.X variant histone; targeted mutation 1, Frederick W Alt

Primary Identifier	MGI:2670743	Allele Type	Targeted
Attribute String	Null/knockout	Gene	H2ax
Transmission	Germline	Strain of Origin	129S6/SvEvTac
Is Recombinase	false	Is Wild Type	false

molecularNote

Endogenous sequence encompassing the promoter, single exon, and poly A site was floxed and subsequently excised via cre-mediated recombination in ES cells, leaving a single loxP site in place of the endogenous gene.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
H2AX<delta>,
H2AX<delta>

earliestPublication:
Bassing CH, et al. (2002) Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A 99(12):8173-8

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

20 Publication categories

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