| Primary Identifier | MGI:2677457 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Grb2 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A G-to-A mutation was introduced into codon 89 to alter this residue in the corresponding protein from a glutamate to a lysine through homologous recombination. A loxP-flanked neomycin selection cassette also introduced into intron 2 was deleted by cre-mediated recombination, resulting in a single loxP site remaining in the intron. This allele expresses a mutant protein and is thought to be hypomorphic. |
