Primary Identifier | MGI:3039800 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Prm2 |
Transmission | Chimeric | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
description | ES cell line was either R1 or BK4. Haploinsufficiency of Prm2 prevents genetic transmission of the mutated allele and generation of non-chimeric heterozygous mice. All phenotype data reported are from chimeric mice. |
molecularNote | A neo cassette replaced 66 bp in exon 1 via homologous recombination. Analysis of 129 derived sperm from chimeras showed reduced PRM1 and PRM2 protein expression. |