| Primary Identifier | MGI:3040629 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Dmp1 |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 6 was disrupted by an IRES-lacZ reporter and floxed neo cassette that replaced sequence encoding Met119 through the end of the gene, including the RGD region. Mutant calvarial cells showed no wild-type mRNA in either Northern blot or RT-PCR. Immunostaining of osteocytes confirmed lack of wild-type protein in mutant mice, and X-gal staining demonstrated lacZ activity in heterozygote hypertrophic chondrocytes, osteoblasts and osteocytes. |
