| Primary Identifier | MGI:3045973 | Allele Type | Targeted |
| Attribute String | Inserted expressed sequence | Gene | Htr3a |
| Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A point mutation was introduced into exon 7, resulting in a valine to serine substitution at residue 290 (V290S). Exon 7 encodes the M2 channel domain. Cre-mediated recombination removed a floxed neo that was inserted into intron 5. PCR confirmed recombination and RT-PCR indicated reduced levels of mRNA in mutants. |
