| Primary Identifier | MGI:3046837 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Fmn1 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| description | Homozygous mutant mice display limb deformities and a low frequency of renal abnormalities, but not renal agenesis or aberrant lung patterning phenotypes. This mutation is a hypomorphic allele, allelic to Grem1tm1Azun. Compound heterozygous mutant mice show a fully penetrant "limb deformity" limb phenotype, but not the phenotypes causing neonatal lethality. Transcription was not detected in the limb bud mesenchyme of compound heterozygous mutant embryos (J:91385). |
| molecularNote | This allele was generated from Fmn1tm1Zlr by crossing to Tg(CMV-cre)1Cgn mice. Cre expression causes the excision of 170 kb containing the remaining exons between 9 and 24; the hygro cassette is also deleted. The predicted protein product is similar to that of Fmn1tm1Zlr in that the translation is out-of-frame after exon 9. In addition, transcription of Grem1 is disrupted owing to the deletion of a Grem1 regulatory region in an Fmn1 intron. |
