| Primary Identifier | MGI:3052677 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(APOA2)3Rub |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | 5 kb of promoter sequence to the human APOA-I gene were fused to human APOA-II coding sequence. 10 copies of the transgene intergrated into the genome of this founder strain. In these mice, human APOA2 mRNA is found only in the liver. Transgenic mice express a dimeric form of human apolipoprotein A-II. Levels of murine HDL, APOA1, and APOA2 in transgenic mice were comparable to those found in normal wildtype siblings. |
