| Primary Identifier | MGI:3054923 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Grem1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | This mutation was determined through complementation analysis to be allelic to Grem1ld-J (J:84077). Heterozygous mutant mice were viable and fertile. Serial skeletal stains of cartilage and bone of heterozygous mutant embryos and newborn mice showed no abnormalities in limb development. |
| molecularNote | The open reading frame, which lies on a single exon, was replaced with an in frame fusion of lacZ with the sequence encoding the first five residues followed by an FRT site flanked neomycin resistance gene cassette. Mice with and without the neo cassette have the same phenotype. LacZ expression in heterozygous mutant mice recapitulates that of wild-type mice. |
