Primary Identifier | MGI:3055500 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Hmx3 |
Transmission | Germline | Strain of Origin | 129 |
Is Recombinase | false | Is Wild Type | false |
description | ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or D3 (129S2/SvPas). |
molecularNote | A targeting vector was designed to replace an 11kb genomic fragment encompassing the Hmx2 and Hmx3 homeoboxes with a neomycin resistance gene. The only potential protein to be translated would be a truncated Hmx3 protein lacking the C-terminal portion essential for DNA-binding. |