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Allele : Mc4r<tm1Lowl> melanocortin 4 receptor; targeted mutation 1, Bradford B Lowell
Primary Identifier  MGI:3512050 Allele Type  Targeted
Attribute String  Conditional ready, Null/knockout Gene  Mc4r
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  A loxP flanked PGK-neomycin selection marker inserted in the 5' UTR created a null allele. Cre recombinase deletes the selection marker, restoring normal activity of the allele. Mice fail to respond to MC4R agonist MTII. This is a null allele that can be "reactivated" by cre recombinase.
  • mutations:
  • Insertion
  • synonyms:
  • Mc4r<tb>,
  • loxTB Mc4r,
  • Mc4r<tb>,
  • loxTB Mc4r
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

81 Publication categories





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