Primary Identifier | MGI:3582594 | Allele Type | Targeted |
Gene | Trp53 | Transmission | Germline |
Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The hormone-binding domain (encoding amino acids 281-599) of a modified estrogen receptor was fused in-frame at the 3' end of the coding sequence. Three new amino acids were introduced at the junction. A Floxed Neo cassette was inserted 580 bp down-stream from the polyadenylation site. The polyadenylation signal and other 3' untranslated sequences were left intact. |