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Allele : Tg(PDGFB-APPSweIndArc)48Lms transgene insertion 48, Lennart Mucke
Primary Identifier  MGI:3603941 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(PDGFB-APPSweIndArc)48Lms
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  These mice express human amyloid protein precursor bearing the Arctic (E22G) mutation, as well as the Swedish (K670N/M671L) and Indiana (V717F) mutations, under control of the human platelet derived growth factor, B polypeptide (PDGFB), promoter. ELISA demonstrated levels of APP and the Beta-secretase-generated C99 fragment, from which amyloid-Beta is cleaved, were higher in this line than Tg(PDGFB-APPSwIND)20Lms in hippocampus.
  • mutations:
  • Insertion
  • synonyms:
  • Arc48,
  • Arc48
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

8 Publication categories





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