Primary Identifier | MGI:3606977 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Spag16 |
Transmission | Chimeric | Strain of Origin | 129/Sv |
Is Recombinase | false | Is Wild Type | false |
description | Haploinsufficiency of Spag16 prevents genetic transmission of the mutated allele and generation of non-chimeric heterozygous mice. All phenotype data reported are from chimeric mice. |
molecularNote | A targeting vector was designed to replace exon 11 with a PGK-neo selection cassette, preventing expression of the 35-kDA protein and the WD repeats of the 71-kDa protein. |