| Primary Identifier | MGI:3608910 | Allele Type | Targeted |
| Attribute String | Conditional ready, No functional change | Gene | Itgb8 |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A pgk-neo flanked by FRT sites with a loxP site at the 3' end was inserted into intron 4. A second loxP site was inserted into intron 3. Crossing with mice expressing FLP recombinase removed the pgk-neo, leaving mice with a flanked exon 4. Exon 4 encodes the integrin I-like domain. Cre-mediated deletion of this exon would result in a translational frameshift that generates a premature stop codon. |
