| Primary Identifier | MGI:3620126 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Trh |
| Transmission | Germline | Strain of Origin | (C57BL/6NCrlj x CBA/JNCrlj)F1 |
| Is Recombinase | false | Is Wild Type | false |
| description | Mice homozygous for a targeted disruption of Trh are viable, fertile, and develop normally. They exhibit, however, a tertiary hypothyroidism with elevated TSH levels, suggesting a direct effect of TRH on pituitary thyrotrophs. Impaired insulin secretion and hyperglycemia also occur in these mice (J:43657). |
| molecularNote | A neomycin selection cassette replaced sequences containing codons 70-211. Northern blot analysis indicated that no detectable transcript was expressed from this allele in hypothalamus, and radioimmunoassy experiments confirmed the absence of encoded protein from homozygous mice. |
