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Allele : Cd80<tm1Lbgn> CD80 antigen; targeted mutation 1, Laurence Bugeon

Primary Identifier	MGI:3653492	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Cd80
Transmission	Germline	Strain of Origin	129S2/SvPas
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin resistance gene was inserted into exon 3 such that only expression of the full-length form of Cd80 is disrupted. Expression of IgV-Cd80 was not disrupted.

mutations:
Insertion

cellLines:
Not Specified

earliestPublication:
Bugeon L, et al. (2001) Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses. Eur J Immunol 31(1):118-27

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

4 Publication categories

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