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Allele : Igk<tm1Rsky> immunoglobulin kappa chain complex; targeted mutation 1, Klaus Rajewsky

Primary Identifier	MGI:3662618	Allele Type	Targeted
Attribute String	Inserted expressed sequence	Gene	Igk
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

A targeting vector was used to insert a floxed neo (subsequently removed via cre mediated recombination) and a recombined Vk3-83-Jk2 region replacing J1 and J2.

mutations:
Intergenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
3-83kappai,
Igk<tm1Pld>,
3-83kappai,
Igk<tm1Pld>

earliestPublication:
Pelanda R, et al. (1996) A prematurely expressed Ig kappa transgene, but not a V kappa J kappa gene segment targeted into the Ig kappa locus, can rescue B cell development in lambda 5-deficient mice. Immunity 5(3):229-239

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

25 Publication categories

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