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Allele : Hsh2d<tm1Viss> hematopoietic SH2 domain containing; targeted mutation 1, Virginia Smith Shapiro

Primary Identifier	MGI:3662663	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Hsh2d
Transmission	Germline	Strain of Origin	(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin resistance cassette replaced exons 2 and 3. These exons encoded the ATG and the SH2 domain FLVR motif. Western blot failed to detect protein in mutants.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
ALX KO,
ALX KO

earliestPublication:
Perchonock CE, et al. (2006) Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX. Mol Cell Biol 26(16):6005-15

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

5 Publication categories

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