| Primary Identifier | MGI:3689957 | Allele Type | Targeted |
| Attribute String | Recombinase | Gene | Mog |
| Transmission | Germline | Strain of Origin | B6.Cg-Thy1<a> |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | The open reading frame of the Cre recombinase gene, followed by the human growth hormone polyadenylation signal and the neomycin resistance gene, has replaced all except the 5'-most segment of the first exon, the first intron and all but the 3'-most part of the second exon of the myelin oligodendrocyte glycoprotein gene, thus targeting Cre expression to oligodendrocytes (ODCs). Western blot analysis demonstrated that wild-type MOG protein is present in heterozygous and wild-type brains at comparable levels, but is not detectable in homozygous mutant brain. |
