| Primary Identifier | MGI:3697323 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Apoc1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | Apoc1 disruption in heterozygous Apoe-deficient ES cells was produced using the same construct used to produce Apoc1-deficiency in E14 ES cells. (J:22858) |
| molecularNote | A replacement vector was used to disrupt exons 1 and 2 of the Apoc1 gene by replacing them with a 2 kb hygromycin B-resistance gene. The vector was transfected into a heterozygous Apoe-deficient E14 ES cell line. Mice produced from the doubly targeted ES cells disrupted alleles of both Apoe and Apoc1. |
