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Allele : Bco1<tm1Dnp> beta-carotene oxygenase 1; targeted mutation 1, Adrian Wyss

Primary Identifier	MGI:3767552	Allele Type	Targeted
Attribute String	Null/knockout, Reporter	Gene	Bco1
Transmission	Germline	Strain of Origin	129S6/SvEvTac
Is Recombinase	false	Is Wild Type	false

molecularNote

An IRES-lacZ gene and floxed neo cassette replaced an 8.8 kb fragment including half of exon 2 and exon 3. Immunoblot analysis of homozygous livers confirmed absence of protein expression.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
CMO1<->,
CMO1<tm1dnp>,
CMO1<tm1dnp>,
CMO1<->

earliestPublication:
Hessel S, et al. (2007) CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice. J Biol Chem 282(46):33553-61

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

30 Publication categories

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