| Primary Identifier | MGI:3800462 | Allele Type | Targeted |
| Attribute String | Not Specified | Gene | Bcl2l11 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A floxed neo cassette was inserted within intron 4, and a specific mutation in exon 4 was introduced by homologous recombination. Mutation resulted in one site of JNK phosphorylation (Thr-112) in exon 4 to be substituted with an Ala (T112A). The neo cassette was then excised with cre recombines leaving a single loxP site in intron 4. Expression of normal amounts of mutant proteins was confirmed by immunoblot. |
